Exposure measurements during high kinetic processing at Zoz. NP release simulation in test chambers and modeling of the scenarios at industrial scale in real environments. 3. Step 3: Hazard assessment. In vitro human hazard testing: EYE (Bovine Corneal Opacity and Permeability BCOP test for EYE irri- tation -OECD TG437), SKIN (since no conclusive results on the former, further testing using SkinEthicTM HCE -OECD TG492 to be carreid out), and LUNG. Ecotoxicity testing will also be carried out: Algae growth inhibition test (OECD TG201) and Daphnia acute immobilisation test (OECD TG202). 4. Step 4: Risk assessment: Comparison exposure values in step 2 with (proposed) occupational exposure limits, identi cation of residual health risks and comparison of emissions to the environ- ment and PNEC values. 5. Step 5: Risk management: Recommendations for safe use (NP general, plant-speci c) will be available and will permit the de - nition of basic procedures and guidelines. Powder production The dispersion of the core-shell systems in the Ti Matrix has to be trans- formed in suitable raw material for additive manufacturing. The usual spherical powder production techniques are considered: Gas Atomisation (GA) and Electrode Induction melting Gas Atomisation (EIGA). Being this a more economical solution for reactive alloys such as Ti, EIGA is a rst candidate for the manufacturing of a spherical nanocom- posite powder (SiC nanoparticles reinforced Ti64 matrix). TLS Technik is the powder producer in the consortium. Technical Data Bar diameter Bar length Production capacity Gas Gas pressure Batch size Mean particle size d50 30-90 mm 200-700 mm 150 t/a Argon 20-35 bar 5 kg – 1 t 5-70 μm The Nanotund3D work ow can be used for other materials following the same productive process Gas Atomisation (EIGA) at TLS Technik AERONAUTICS The raw material of the EIGA process is a bar of the nanocomposite material. Non-spherical nanocomposite powders of SiC reinforced Ti64 are manufactured at Zoz GmbH using a roll-mill. RM1, and the Simoloyer CM01 equipment, a design for High Kinetic Processing (HKP). The nanocomposite powder was shaped into bars following two methodologies: Samples were hot pressed into an EIGA bar of 55 mm diameter at 500 °C for 5 min and 1.000 MPa at Zoz GmbH. >>35