PRINCIPIOS ACTIVOS CRITERIA CATEGORY(PB ECL - CONTROL BANDING 1 2 3A 3B 4 ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ............................................................................................................C.L.P.:.C.a.t.3.................C.L.P.:.C.a.t.2.................C.L.P.:.C.a.t.1..................... .....................................................................................C.L.P.:C..a.t.4............................................................................................ ........................................................................................................................................................................................ TOXICOLOGIC ........................................................................................................................................................................................ .......................A.c.u.t.e.t.ox.i.ci.ty..(o.r.a.l).D.L.5.0..(m..g./k.g.)...............>..20.0.0.................2.0.0.0.-..3.0.0.0........................................................................................... ..............................................................................................................H.3.0.1.....................H.3.0.0.....................H.3.0.0.0...................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ............................................................................................................C.L.P.:.C.a.t.3.................C.L.P.:.C.a.t.2.................C.L.P.:.C.a.i.1..................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ H302 ........................................................................................................................................................................................ ........................................................................................................................................................................................ ...............................A.c.u.te..to.x.ic.i.ty.....................>.2.0.0.m..g./k.g.............1.0.0.0.2.0.0.0..m.g./.k.g..........1.0.0.0..-.2.0.0.m..g./k.g............2.00..-.5.0.0.m..g./k.g...............<..5.0.m.g./.k.g.................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ .............................(.D.L.5.0.) .(d.e.r.m./.in.h.)....................>.2.0..m.g./.l...............1.0.-..2.0.m..g/.l...............1.0.-.2..m.g./.l...............2..-.0.,5..m.g./.l................<..0.,5..m.g./.l.................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ 300 - 50 50 - 5 < 5 CLP: Cat 4 CLP: Cat.3 CLP: Cat 2 CLP: Cat 1 ........................................................................................................................................................................................ ........................................................................................................................................................................................ .....................................................................................H.3.1.2./H.3.3.2................H.3.1.1./H.3.3.1.................H.3.1.0./H.3.3.0.................H.3.1.0./.H.3.3.0.................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ .......................R.e.p.e.a.t.ed..d.o.se..to.x.ic.i.ty..m.g./.kg./.d.a.y........................................................................................................................................ ...............................................................>..1.0.0...................1.0.-.1.0.0...................1.0.-.1....................1.-.0..-.1....................<..0.,1....................... ........................................................................................................................................................................................ ..........................(.N.O.A.E.L./N.O.E.L.).p.e.r.s.p.e.c.ie.s........................................................................................................................................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ....................R.e.pr.o.d.u.c.ti.v.e.a.n.d.D.e.v.e.lo.p.m..en.t.t.o.x.ic.it.y.m..g./.................................................................................................................................... ............................................................................................................C.L.P.:.C.a.t.2................C.L.P.:.C.a.t.1.B.................C.L.P.:.C.a.t.1.A.................... ........................................................................................................................................................................................ .................................k.g./.d.a.y.................................................................................................................................................. ...............................................................>..3.0.0...................3.0.0.-.3.0...................3.0.-.3....................3..-.0.,3.....................<..0.,3....................... ...............................(N.O.A.E.L./.N.O.E.L.)............................................................................................................................................... ........................................................................................................................................................................................ ..............................................................................................................H.3.6.1.....................H.3.6.0.....................H.3.6.0....................... ...........................p.er.s.p.e.c.ie.s..(r.a.b.b.it.o.r.r.a.t ........................................................................................................................................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ............................................................................................................C.L.P.:.C.a.t.2..................................................................... ...................................................................................................................................C.L.P.:.C.a.t.1.B.................C.L.P.: .C.a.t .1.A.................... ........................................................................................................................................................................................ (mg/kg ppmV. mg/1 > 2500 ppm V 2000 - 2500 ppm V 2500 - 500 ppm V 500 - 100 ppm V < 100 ppm V ........................................................................................................................................................................................ ...............................G.e.n.o.t.o.xi.c.it.y........................N.o.n.e..............N.o.r.e.le.v.a.n.t.e.v.id.e.n.c.e..................................P.o.s.it.iv.e.i.n.v.i.tr.o.............P.o.s.i.ti.v.e.in..v.it.ro................... .........................................................................................................m.a.l.a.b.e.r.ra.t.io.n.t.e.s.t ................................................................. ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..............................................................................................................H.3.4.1....................................................................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ................................................................................P.o.s.it.iv.e.d.a.t.a.i.n.a.n.i.m.a.l....................................................................................... ..............................C.a.r.c.in.o.g.e.n.ic.it.y.......................N.o.n.e..........................................C.L.P.:C.a.t.2................C.L.P.:.C.a.t.1.B.................C.L.P.:.C.a.t.1.A.................... .....................................................................................s.tu.d.i.e.s.a.t............................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ Positivite in vitro chromoso- H340 H340 ........................................................................................................................................................................................ ........................................................................................................................................................................................ ................................C.R.I.T.E.R.I.A................................................................................................................................................. ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ .....................................................................................................S.u.s.p.e.c.te.d..of.c.a.u.s.i.ng..c.a.n.c.er....E.vi.d.e.n.ce..o.f .c.au.s.i.n.g.c.a.n.c.e.r ....E.v.id.e.n.c.e.o.f.c.a.u.s.in.g..ca.n.c.e.r.............. ................................................................................h.ig.h..o.r.s.p.ec.i.e.s.s.p.e.ci. .c....................................................................................... ........................................................................................................................................................................................ CATEGORY (PB - ECL - CONTROL BANDING) 1 2 3A 2B 4 ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ............................................................................................................................................................C.L.P.:.C.a.t.1..................... ....................................................................................................................................C.L.P.:.C.a.t.1............................................. ........................................................................................................................................................................................ H351 H350 H350 ........................................................................................................................................................................................ ..............................................................................................................................E.v.id.e.n.c.e.i.n.s.k.in..to.x.ic.o.lo.g.y....................................... ...............................S.e.n.s.it.iz.a.ti.o.n.....................N.o.s.e.n.s.it.iz.e.r .............W.i.t.ho.u.t.e.f.fe.c.t.s.............L.o.c.a.l .e.ff.e.ct.s..................................a.t.r.e.s.p.ir.a.to.r.y .le.v.e.l .(S.e.v.e.re............... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..............................................................................................................H.3.1.7............................................s.ys.t.e.m.ic.)..................... ......................................................................................................................................H.3.1.7............................................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ....................................................................... ....................... ......................... .................... ..................................O..E.L .......................>.1.0.0.0.m..c.g./m............1.0.0..-.1.0.0.0.m..c.g./m............1.0.0.-.1.0..m.c.g./.m.............1.0..-.1.m..c.g./m.................<..1.m.c.g./m...................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................P.H.A.R.M..A.C..O.L.O.G.I.C.................................................................................. ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ...................... CLP: Cat1 Evidence toxicology studies studies (Moderate systemic) ....................... H334 3 3 3 3 3 ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ...............................R.e.v.e.rs.i.b.il.it.y......................R.e.ve.r.s.ib.l.e................R.e.v.e.rs.ib.l.e.............P.a.r.ti.a.ll.y.re.v.e.r.si.b.le..........Ir.re.v.e.rs.i.b.le..n.o.c.ri.ti.c.a.l ............I.rr.e.ve.r.s.ib.l.e.................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ....................................................................................................................................................S.e.r.io.u.s.a.d.v.e.r.s.e.e.ff.e.c.ts.w..it.h.o.u.t ............ ........................................................................................................................................................................................ Adverse effects Very low Low Moderate Serious Very serious ........................................................................................................................................................................................ ............................................................................................................................................................s.y.m.p.t.o.m.s..................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ .............................C.o.n.t.ra.i.n.d.ic.a.t.io.n.s......................N.o.n.e....................L.o.w....................M.o.d.e.ra.t.e..................S.e.r.io.u.s..................V.e.ry.s.e.r.io.u.s.................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..........................E.l.im..in.a.t.io.n..ha.l.f.-l.if.e.(.t..)..................R.a.p.i.d....................R.a.p.id...................M.o.d.e.ra.t.e...................S.l.ow....................C.u.m.u.l.a.ti.v.e.................... Onset of warning symptoms No adverse effects Immediate Mid-term effects Long-term effects ........................................... ............................................................................................................................................ . ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ .....................T.h.er.a.p.e.u.ti.c.d.o.s.e.o.r.P.o.te.n.e.y.*.*.(.m.g./.d.a.y).............>..1.0.0..................>.1.0.0..- .1.0.................>..1.0.-.1..................>..1.0.-.0.,.1...................<..0.,1....................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..............................................................................M..a.y.b.e.r.e.q.u.ir.ed..b.u.t.n.o.t .li.fe...................................................................................... ............................M.e.d.i.ca.l.O.n.t.e.rv.e.n.t.io.n..................N.o.t.r.eq.u.i.re.d........................................R.e.q.u.ir.e.d..................R.eq.u.i.re.d..............I.m.m..e.di.a.t.el.y.r.eq.u.i.re.d................. ........................................................................................................................................................................................ ....................................................................................t.h.r.ea.t.e.n.in.g............................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................P.H.A.R.M..A.C..O.L.O.G.I.C.................................................................................. ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..............................A.d.v.e.rs.e..ef.f.ec.t.s......................Ve.r.y.l.ow....................L.o.w....................M.o.d.e.ra.t.e..................S.e.r.io.u.s..................V.e.ry.s.e.r.io.u.s.................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ 1 /2 ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ....................................................................................................................................................S.e.r.io.u.s.a.d.v.e.r.s.e.e.ff.e.c.ts.w..it.h.o.u.t ............ .........................O.n.s.e.t.o.f.w.a.r.n.in.g..s.ym..p.to.m..s.............N.o.a.d.v.e.rs.e.e.f.fe.c.t.s.............Im..m.e.d.ia.t.e..............M.i.d.-t.e.rm..e.f.fe.c.t.s...........L.o.n.g.-t.e.r.m.e.f.f.ec.t.s.......................................... ............................................................................................................................................................s.y.m.p.t.o.m.s..................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ Reversibility Reversible Reversible Partially reversible Irreversible no critical Irreversible ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..........................E.l.im..in.a.t.io.n..ha.l.f.-l.if.e.(.t..)..................>..1.0.0..................>.1.0.0..-.1.0.................>..1.0.-.1..................>..1.0.-.0.,.1...................<..0.,1....................... Contraindications None Low Moderate Serious Very serious . ............................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..............................................................................M..a.y.b.e.r.e.q.u.ir.ed..b.u.t.n.o.t .li.fe...................................................................................... .....................T.h.er.a.p.e.u.ti.c.d.o.s.e.o.r.P.o.te.n.e.y.*.*.(.m.g./.d.a.y)...........N.o.t.r.eq.u.i.re.d........................................R.e.q.u.ir.e.d..................R.eq.u.i.re.d..............I.m.m..e.di.a.t.el.y.r.eq.u.i.re.d................. ........................................................................................................................................................................................ ....................................................................................t.h.r.ea.t.e.n.in.g............................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ...............................................................................................C.A.T.E.G.O..R.Y..(P.B..-.E.C.L..-.C.O..N.T.R.O.L..B.A.N..D.IN..G.)..................................................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................... 1 /2 ........................................................................................................................................................................................ ........................................................................................................................................................................................ .................................................................1.......................2.......................3.A.......................3.B........................4........................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..............................................................................C.H.E.M..I.C.A.L..A.N.D..P.H..Y.S.I.C.A.L..P.R.O.P.E.R..T.IE.S......................................................................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ...............................................................................S.li.g.h.t.t.o.m.o.d.e.r.at.e.i.rr.i.ta.n.t.........S.e.ve.r.e.i.rr.it.a.n.t...............C.o.r.r.os.i.v.e............................................. ........................................................................................................................................................................................ ...........................Ir.ri.ta.t.io.n..(e.y.e.s.a.n.d.s.k.i.n.)...............N.o.t.a.n.d.i.rr.it.a.n.t.........................................................................................-........................ .....................................................................................H.3.1.6./H.3.2.0................H.3.1.5./H.3.1.9.................H.3.1.4./H.3.1.8............................................. ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ..........................A.c.u.t.e.w.a.r.n.in.g..p.ro.p.e.r.ti.es..................E.x.c.e.ll.en.t...................G.o.o.d....................P.o.o.r.....................P.o.o.r.....................N..on.e....................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ...................F.i.g.u.r.a..3. .C.r.it.e.r.i.o.s.t.o.x.i.c.o.ló.g.i.c.o.s..y.f.a.r.m.a..c.o.ló.g.i.c.o.s..p.a.r.a.l.a..c.a.te..g.o.r.iz.a.c.i.ó.n..................................................................................................... ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ ........................................................................................................................................................................................ CRITERIA >>17